Marcel M Verbeek Selected Research

Familial Cerebral Amyloid Angiopathy

1/2017	β-Amyloid in CSF: Biomarker for preclinical cerebral amyloid angiopathy.
4/2010	Aggregation and cytotoxic properties towards cultured cerebrovascular cells of Dutch-mutated Abeta40 (DAbeta(1-40)) are modulated by sulfate moieties of heparin.
2/2010	Apolipoprotein E protects cultured pericytes and astrocytes from D-Abeta(1-40)-mediated cell death.
2/2009	Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion.
12/2007	Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells.
2/2006	Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity.
1/2004	Insulin inhibits amyloid beta-induced cell death in cultured human brain pericytes.
10/2002	Inhibition of amyloid-beta-induced cell death in human brain pericytes in vitro.

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Marcel M Verbeek Research Topics

Disease

83	Alzheimer Disease (Alzheimer's Disease) 10/2022 - 07/2002
30	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 10/2022 - 10/2002
27	Dementia (Dementias) 04/2022 - 10/2004
20	Parkinson Disease (Parkinson's Disease) 05/2022 - 05/2004
17	Cognitive Dysfunction 10/2022 - 07/2013
13	Amyloid Plaque 01/2021 - 07/2002
9	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2021 - 10/2009
8	Familial Cerebral Amyloid Angiopathy 01/2017 - 10/2002
8	Frontotemporal Dementia (Semantic Dementia) 01/2017 - 01/2009
7	Parkinsonian Disorders (Parkinsonism) 11/2021 - 07/2008
6	Movement Disorders (Movement Disorder) 05/2022 - 08/2008
6	Multiple System Atrophy 11/2021 - 05/2004
6	Inflammation (Inflammations) 01/2020 - 04/2006
6	Synucleinopathies 01/2017 - 10/2004
4	Glut1 Deficiency Syndrome 01/2017 - 09/2013
4	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 07/2014 - 07/2006
3	Intellectual Disability (Idiocy) 05/2022 - 03/2010
3	Disease Progression 01/2020 - 01/2017
3	Multiple Sclerosis 01/2020 - 11/2012
3	Neuromyelitis Optica (Devic's Disease) 01/2020 - 06/2012
3	Atrophy 01/2018 - 01/2014
3	Inclusion Body Myositis 04/2016 - 09/2009
3	Lewy Body Disease (Lewy Body Dementia) 09/2015 - 07/2013
3	Nervous System Diseases (Neurological Disorders) 12/2013 - 05/2007
2	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 11/2021 - 04/2011
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2021 - 10/2009
2	Orthostatic Hypotension (Postural Hypotension) 01/2021 - 01/2018
2	autosomal recessive Segawa syndrome 01/2021 - 06/2010
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 12/2017 - 01/2014
2	Cerebral Small Vessel Diseases 01/2017 - 01/2017
2	Dermatomyositis (Dermatopolymyositis) 04/2016 - 03/2013
2	Brain Diseases (Brain Disorder) 01/2015 - 01/2010
2	Muscle Hypotonia (Hypotonia) 04/2014 - 01/2012
2	Dystonia (Limb Dystonia) 04/2014 - 01/2012
2	Coma (Comas) 10/2013 - 02/2012
2	Hypertension (High Blood Pressure) 12/2012 - 01/2008
2	Neoplasms (Cancer) 01/2008 - 09/2006
2	Neoplasm Metastasis (Metastasis) 09/2006 - 09/2005
1	Gliosis 04/2022
1	Cerebral Hemorrhage 01/2022
1	Stroke (Strokes) 01/2022
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 11/2021
1	Glioma (Gliomas) 01/2021

Drug/Important Bio-Agent (IBA)

69	Biomarkers (Surrogate Marker)IBA 10/2022 - 01/2007
40	Amyloid (Amyloid Fibrils)IBA 01/2022 - 10/2002
24	Proteins (Proteins, Gene)FDA Link 11/2021 - 09/2005
24	Amyloid beta-PeptidesIBA 01/2021 - 07/2002
9	Peptides (Polypeptides)IBA 11/2021 - 09/2005
8	SynucleinsIBA 04/2021 - 01/2010
6	EnzymesIBA 03/2021 - 12/2002
6	tau Proteins (tau Protein)IBA 10/2016 - 05/2007
5	Levodopa (L Dopa)FDA LinkGeneric 05/2022 - 08/2008
5	Apolipoproteins E (ApoE)IBA 01/2022 - 04/2005
5	Glucose (Dextrose)FDA LinkGeneric 12/2013 - 03/2010
5	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 04/2010 - 07/2002
4	ApolipoproteinsIBA 01/2018 - 04/2005
4	alpha-SynucleinIBA 09/2015 - 10/2004
3	Glial Fibrillary Acidic ProteinIBA 04/2022 - 01/2010
3	Biological ProductsIBA 01/2022 - 10/2016
3	Pharmaceutical PreparationsIBA 01/2019 - 08/2012
3	Protein Isoforms (Isoforms)IBA 01/2018 - 01/2015
3	MicroRNAs (MicroRNA)IBA 12/2017 - 01/2014
3	AutoantibodiesIBA 04/2016 - 03/2013
3	ImmunosorbentsIBA 09/2015 - 12/2002
3	MethoxyhydroxyphenylglycolIBA 07/2014 - 01/2011
3	OrexinsIBA 01/2013 - 10/2009
3	Small Heat-Shock ProteinsIBA 02/2009 - 02/2006
2	Glucose-6-Phosphate Isomerase (Phosphoglucose Isomerase)IBA 11/2021 - 01/2021
2	Nerve Growth Factors (Neurotrophins)IBA 11/2021 - 01/2021
2	Glutamate-Ammonia Ligase (Glutamine Synthetase)IBA 01/2020 - 03/2015
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2018 - 12/2013
2	AntibodiesIBA 01/2018 - 03/2013
2	EpitopesIBA 04/2016 - 10/2002
2	5'-Nucleotidase (5' Nucleotidase)IBA 04/2016 - 03/2013
2	CatecholaminesIBA 08/2015 - 06/2010
2	AntigensIBA 09/2014 - 11/2012
2	Lactic Acid (Lactate)FDA LinkGeneric 11/2013 - 01/2012
2	Phosphopyruvate Hydratase (Enolase)IBA 10/2013 - 02/2012
2	Complement System Proteins (Complement)IBA 06/2012 - 01/2010
2	Homovanillic AcidIBA 06/2010 - 10/2007
2	GlycosaminoglycansIBA 04/2010 - 10/2004
2	ChemokinesIBA 09/2006 - 04/2006
2	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 02/2006 - 08/2005
2	CytokinesIBA 08/2005 - 11/2002
1	Aromatic-L-Amino-Acid DecarboxylasesIBA 05/2022
1	VS 215IBA 04/2022
1	antineoplaston A10 (A 10)IBA 01/2022
1	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 01/2022
1	Plasminogen Activators (Plasminogen Activator)IBA 01/2022
1	Ataxin-3IBA 11/2021
1	polyglutamineIBA 11/2021
1	Antisense OligonucleotidesIBA 10/2021
1	Leucine (L-Leucine)FDA Link 01/2021
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2021
1	gamma-Aminobutyric Acid (GABA)IBA 01/2021
1	chitotriosidaseIBA 01/2021

Therapy/Procedure

3	Therapeutics 01/2018 - 10/2002
2	Immunotherapy 01/2022 - 11/2017
2	Ketogenic Diet 09/2013 - 03/2010
1	Lasers (Laser) 01/2021